Label-free Kinetic Characterization for Accelerated Drug Discovery

Agile R100 is an optics-free assay troubleshooting tool that puts validation of results in your personal control. With options for measurement of weak and tight binders or unstable membrane proteins, you can capture elusive binding data for all your compounds.

Label-free Characterization of Small Molecules and Proteins

Agile R100 is an optics-free assay troubleshooting tool that puts validation of results in your personal control. With options for measurement of weak and tight binders or unstable membrane proteins, you can capture elusive binding data for all your compounds.

Agile R100 binding assay for characterization of small molecules and proteins

LABEL-FREE

Make direct measurements
to reduce assay complexity

Agile R100 binding assay for characterization of small molecules and proteins

FAST

Run an assay in 2 minutes or
study Koff for over 8 hours

Agile R100 binding assay for characterization of small molecules and proteins

AFFORDABLE

Confirm binding interactions and
gather kinetics at a low cost

AMAZING FEATURES

Undeterred by solvents or detergents, Agile R100 detects the weakest interactions in low concentrations to deliver small molecule and protein data not possible before.

11-LOG DYNAMIC RANGE
From 100 fM to 10 mM, develop weakly-binding fragments and high-affinity compounds with one platform.

10 µL DROP OF SAMPLE
Get more information from less material and reduce your cost to data.

> 10 Da SMALL MOLECULES
Accurately detect the smallest molecules for flexible drug discovery unlimited by molecule size.

11-LOG DYNAMIC RANGE
From 100 fM to 10 mM, develop weakly-binding fragments into high-affinity compounds on one platform.

10 µL DROP OF SAMPLE
Get more information from less material and reduce your cost to data.

> 10 Da SMALL MOLECULES
Accurately detect the smallest molecules for flexible drug discovery unlimited by molecule size.

Agile R100 has high sensitivity and ability to sense in serum

COMPLEX MATRIX COMPATIBLE
Small molecules and proteins can be detected in 10% DMSO, detergents, cell lysate, serum, or plasma.

0.5-500 ng IMMOBILIZED TARGET
Ideal for difficult-to-express membrane proteins, when you only have a tiny bit of sample.

2 MINUTES TO 8+ HOURS
Study unstable molecules, fast-acting drugs, or interactions with slow off-rates not possible with other methods.

COMPLEX MATRIX COMPATIBLE
Small molecules and proteins can be detected in 10% DMSO, detergents, cell lysate, serum, or plasma.

0.5-500 ng IMMOBILIZED TARGET
Ideal for difficult-to-express membrane proteins, when you only have a tiny bit of sample.

2 MINUTES TO 8+ HOURS
Study unstable molecules, fast-acting drugs, or interactions with slow off-rates not possible with other methods.

VERSATILE APPLICATIONS

kinetic characterization with Agile R100 label-free graphene biosensorKINETIC CHARACTERIZATION
Rather than calculate KD from EC/IC50 values, make a direct measurement to ensure accuracy.

GPCR analysis with Agile R100 label-free Graphene biosensorGPCR ANALYSIS
Low target density requirements and the ability to use solubilizing detergents make it easy to study GPCRs.

Agile R100 label-free graphene biosensor for affinity rankingAFFINITY RANKING
Verify compounds provided to chemists during SAR to ensure accurate results.

Agile R100 label-free graphene biosensor for protein-protein interactionsPROTEIN-PROTEIN INTERACTIONS
Easily characterize the interactions needed to translate in vitro activity to in vivo drug efficacy.

NEW DISCOVERIES

Accurate small molecule and protein characterization can take your drug discovery program to the next level, but until now, it’s been too expensive and difficult to get kinetic binding data on your own terms. If you want to save time, cost, and resources, Agile R100 puts the power in your hands. See how Agile R100 is used in this 2-minute video!

OUR CUSTOMERS AND COLLABORATORS

CDC logo
Mayo Clinic evaluating the diagnostic capabilities of field effect biosensor chips.
Stanford School of Medicine using AGILE R100 for in vitro kinetic binding data.
Stanford School of Medicine using AGILE R100 for in vitro kinetic binding data.
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Abilita Bio logo
Abreos biosciences logo
Base Pair Biosciences logo

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