Label-free Validation of Proteins and Small Molecule Compounds

Agile R100 is an optics-free assay troubleshooting tool that puts validation of results in your personal control. With options for measuring weak and tight binders or unstable proteins, now you can capture elusive binding data for all your compounds.

Label-free Validation of Proteins and Small Molecule Compounds

Agile R100 is an optics-free assay troubleshooting tool that puts validation of results in your personal control. With options for measuring weak and tight binders or unstable proteins, now you can capture elusive binding data for all your compounds.

Agile R100 binding assay for characterization of small molecules and proteins

FAST

Run an assay in 2 minutes or
study Koff for over 8 hours

Agile R100 binding assay for characterization of small molecules and proteins

AFFORDABLE

Confirm binding interactions and
gather kinetics at a low cost

Agile R100 graphene biosensor for label-free kinetic characterization

COMPACT

Save bench space and gain portability with a 9″ x 3″, 2 lb. instrument

AMAZING FEATURES

Graphene-based biosensor Agile R100 detects the weakest interactions in low concentrations to deliver small molecule and protein data not possible before.

11-LOG DYNAMIC RANGE
From 100 fM to 10 mM, develop weakly-binding fragments and high-affinity compounds with one platform.

10 µL DROP OF SAMPLE
Get more information from less material and reduce your cost to data.

> 10 Da SMALL MOLECULES
Accurately detect the smallest molecules for flexible drug discovery unlimited by molecule size.

11-LOG DYNAMIC RANGE
From 100 fM to 10 mM, develop weakly-binding fragments into high-affinity compounds on one platform.

10 µL DROP OF SAMPLE
Get more information from less material and reduce your cost to data.

> 10 Da SMALL MOLECULES
Accurately detect the smallest molecules for flexible drug discovery unlimited by molecule size.

Agile R100 has high sensitivity and ability to sense in serum

COMPATIBLE WITH COMPLEX MATRICES
Small molecules and proteins can be detected in 10% DMSO, detergents, cell lysate, serum, or plasma.

0.5-500 ng IMMOBILIZED TARGET
Ideal for difficult-to-express membrane proteins, when you only have a tiny bit of sample.

2 MINUTES TO 8+ HOURS
Study unstable molecules, fast-acting drugs, or interactions with slow off-rates not possible with other methods.

COMPATIBLE WITH COMPLEX MATRICES
Small molecules and proteins can be detected in 10% DMSO, detergents, cell lysate, serum, or plasma.

0.5-500 ng IMMOBILIZED TARGET
Ideal for difficult-to-express membrane proteins, when you only have a tiny bit of sample.

2 MINUTES TO 8+ HOURS
Study unstable molecules, fast-acting drugs, or interactions with slow off-rates not possible with other methods.

VERSATILE APPLICATIONS

kinetic characterization of weak binders with label-free Agile R100 graphene biosensorWEAK BINDERS
Optics-free Agile R100 can detect weak binding of small molecules with small amount of target.

kinetic characterization of tight binders with label-free Agile R100 graphene biosensorTIGHT BINDERS
High-affinity interactions can bottom out with a labeled assay. Make direct measurements to ensure accuracy.

GPCR characterization with label-free Agile R100 graphene biosensorUNSTABLE PROTEINS LIKE GPCRs
Validate binding of GPCRs, ion channels, transporters, and other unstable proteins.

measure undruggable targets for small molecules and proteins with Agile R100 graphene biosensorUNDRUGGABLE TARGETS
Graphene is a biologically nonreactive material that minimizes non-specific binding.

kinetic characterization of small molecules and proteins with Agile R100 label-free graphene biosensorCOMPLEX SAMPLES
Quickly check compounds not soluble in aqueous buffer and skip solvent correction.

kinetic characterization of small molecules and proteins with Agile R100 label-free graphene biosensorKINETIC CHARACTERIZATION
Verify SAR results with sensitive kinetic binding affinity KD, on-rates (kon) and off-rates (koff).

NEW DISCOVERIES

Accurate small molecule and protein characterization can take your drug discovery program to the next level, but until now, it’s been too expensive and difficult to get kinetic binding data on your own terms. If you want to save time, cost, and resources, Agile R100 puts the power in your hands. See how Agile R100 is used in this 2-minute video!

TRUSTED BY TOP RESEARCHERS

CDC logo
Mayo Clinic evaluating the diagnostic capabilities of field effect biosensor chips.
Stanford School of Medicine using AGILE R100 for in vitro kinetic binding data.
Stanford School of Medicine using AGILE R100 for in vitro kinetic binding data.

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