AGILE R100: An Orthogonal BiosensingTool for Structure Activity Relationship (SAR) Studies During Early Stage Drug Discovery

Drug Discovery Chemistry Conference in San Diego, 2017

A simple SAR study was performed with AGILE R100 using TNFα as the immobilized target and various inhibitor compounds as analyte. Dose-response curves and kinetic binding data quantify the activity and affinity of the three compounds interacting with the target.

Direct Detection of Borrelia Burgdorferi Antigen Using Field Effect Biosensing (FEB) Technology

Centers for Disease Control and Prevention (CDC) in Atlanta, 2016

Detecting various concentrations of lysed Borrelia burgdorferi cells with AGILE R100.

AGILE Sensors Quantify Interactions in Challenging Samples for Drug Discovery

Drug Discovery Chemistry Conference in San Diego, 2016

Results shown from measurements with quantity-limited samples (50 µg of total protein) and at fM concentration.

Novel Protein Binding Kinetics Measurements in Complex Biological Samples Using AGILE

Experimental Biology Conference in San Diego, 2016

Results shown from measurements directly from cell lysate, protein extract, growth media, tissue lysate, and undiluted plasma.