AGILE R100: An Orthogonal BiosensingTool for Structure Activity Relationship (SAR) Studies During Early Stage Drug Discovery
Drug Discovery Chemistry Conference in San Diego, 2017
A simple SAR study was performed with AGILE R100 using TNFα as the immobilized target and various inhibitor compounds as analyte. Dose-response curves and kinetic binding data quantify the activity and affinity of the three compounds interacting with the target.
Centers for Disease Control and Prevention (CDC) in Atlanta, 2016
Detecting various concentrations of lysed Borrelia burgdorferi cells with AGILE R100.
Drug Discovery Chemistry Conference in San Diego, 2016
Results shown from measurements with quantity-limited samples (50 µg of total protein) and at fM concentration.
Experimental Biology Conference in San Diego, 2016
Results shown from measurements directly from cell lysate, protein extract, growth media, tissue lysate, and undiluted plasma.